Product Description

Description:

Magnolia bark P.E is a fluid alcohol extracted from the bark of a magnolia plant and frequently administered as an herbal medicine.

It has been used in traditional Chinese medicine called houpu or hou po for hundreds of years and is widely recognized worldwide forits medicinal properties.

Magnolia bark extract is used to treat a variety of conditions and symptoms, especially for upset stomach, allergic reactions, impairedbreathing, anxiety, weight loss, and halitosis.

The active ingredients in the medicine are present in almost all species of magnolia, but the magnolia officinalis, or Houpu magnolia, isthe most frequently used.

The primary active ingredients in magnolia bark extract are magnolol and honokiol, biphenol compounds, which are thought to reducestress and stress-related symptoms and inhibit cortisol. Cortisol is a hormone associated with stress and flight or fight responses, as

well as weight gain, diabetes, and immunosuppression. Magnolia bark extract also contains eudesmol, an essential oil with possibleantioxidant advantages.

Antioxidants repair and prevent cellular oxidative damage caused by free radicals, which can lead to increased cell fortitude, increasedimmune function, and decreased risk of heart disease and cancer. The magnolia flower is sometimes used to treat sinus congestion andheadaches.

Honokiol is present in magnolia bark at about one to five percent, and magnalol is present at roughly two to ten percent. Typical dosesuse three to nine grams of bark in hot water. Other traditional formulas include pin yin for constipation and congestion, which

incorporates different proportions of magnolia bark extract, rhubarb, and chih-shih depending on its targeted function. Pin yin formulasfor digestive system weakness tend to mix magnolia bark with ginger and licorice. Respiratory issues are often treated with formulas

mixing magnolia bark extract and cinnamon twig.

Magnolia bark P.E is also used to treat halitosis, or bad breath, due to its antibacterial properties and fragrance. The antibacterialactivity of the extract may also help to prevent tooth decay and is thought to kill most halitosis-associated oral bacteria within thirtyminutes. Magnolol can also help prevent plaque build-up by inhibiting the enzyme glucotransferase. Some chewing gums and breathmints are manufactured with the extract to promote fresh breath and tooth health.

Magnolia bark P.E usually comes from cultivated trees, typically in China. It is usually marketed in capsule or tablet form, especiallyin the Western world. No adverse effects have been associated with the use of normal dosages of magnolia bark extract. The herbalmedicine should not be taken, however, with any drugs that act on the central nervous system, such as barbiturates, alcohol, or moodaltering medications. Tuhoupu, an herb made from manglietia, is sometimes used as a substitute for magnolia bark.

Pharmacological Action:

1. Inhibit secretion of acidity, Anti-dental caries and anti-periodontal disease.

2. Anti-tumor and cancer: Inhibits or prevents the growth or development of malignant cells. A potential anti-cancer material.

3. Anti-inflammatory and canker.

4. Anti-anxiety: Relax striated muscles,reduce blood pressure, use for anti-stress, anti-depressive and improving sleep.

5. Powerful antioxidant protection: 1000 times more potent than vitamin E in inhibiting lipid peroxidation,a major contributor to

atherosclerosis and heart diseases. It’s effective in cardiovascular diseases.

FUNCTIONS:

Anti-tumorigenic activities

Honokiol has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia,

bladder, lung, prostate, oral squamous cell carcinoma andcolon cancer cell lines.

Honokiol inhibits phosphorylation of Akt, p44/42 mitogen-activated protein kinase (MAPK), and src.

Additionally, honokiol regulates the nuclear factor kappa B (NF-κB) activation pathway,

an upstream effector of vascular endothelial growth factor (VEGF), MCL1, andcyclooxygenase 2 (COX-2), all significant pro-angiogenic and survival factors.

Neurotrophic activity

Honokiol has been shown to promote neurite outgrowth and have neuroprotective effects in rat cortical neurons.

Additionally, honokiol increases free cytoplasmic Ca2+ in rat cortical neurons.

Honokiol is a weak cannabinoid CB2 receptor ligand but the naturally occurring derivative 4-Omethylhonokiol

was shown to be a potent and selective cannabinoid CB2 receptor inverse agonist and to possess

antiosteoclastic effects.

Anti-thrombotic activity

Honokiol inhibits platelet aggregation in rabbits in a dose-dependent manner, and protects cultured RAEC against oxidized low densitylipoprotein injury.

Honokiol significantly increases the prostacyclin metabolite

6-keto-PGF1alpha, potentially the key factor in honokiol's anti-thrombotic activity.

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